患糖尿病的大龄妇女患结肠癌的风险更高_英语科普_英文阅读网

网站地图RSS订阅高级搜索收藏本站首页英语新闻英语散文英语故事英语笑话英语科普英语娱乐英语诗歌英语演讲英语试题英语行业英语小说英语技巧英语论坛英语书店首页英语科普热门标签:lifespacefoodgovernmentclimateheart只需30秒,测测你的英语词汇量!患糖尿病的大龄妇女患结肠癌的风险更高文章来源:未知 文章作者:meng 发布时间:2010-05-03 02:29字体: [大 中 小]  进入论坛(单词翻译:双击或拖选)A research team led by Mayo Clinic physicians has found that older women with diabetes1(糖尿病) face a more than doubled risk for some types of colorectal cancer(结肠直肠癌) . The findings are being presented at Digestive Disease Week 2010, the annual meeting of the American Gastroenterological Association. Colorectal cancer (http://www.mayoclinic.org/colon2-cancer/) remains3 the third-leading cause of cancer deaths among women in the United States. Diabetes has been identified as a colon cancer risk factor, but the mechanisms4 arent completely understood. For this population-based cohort study(定群研究) , researchers examined data from 37,695 participants of the Iowa Womens Health Study (IWHS), which enrolled5 women ages 55 in 1986 and remains ongoing6. Of these women, 2,361 reported a diagnosis7 of Type 2 diabetes and 1,200 developed colorectal cancer.To find the links between colorectal cancer and diabetes, the researchers worked with regional pathology(病理学) laboratories to obtain tumor8 tissue samples from IWHS participants who were diagnosed with colorectal cancer. They linked the tissue samples with other IWHS data, looking for cancer pathways and risk factors, and whether those risk factors were associated with three different molecular9 markers: microsatellite instability (MSI), CpG island methylation (CIMP), and BRAF gene10 mutations.”Diabetes was more strongly associated with the MSI-high, CIMP-positive and BRAF-mutation cancer subtypes in this group of older women,” says Mayo Clinic gastroenterologist Paul Limburg, M.D. (http://www.mayoclinic.org/bio/10658084.htm). Dr. Limburg explains that diabetes appeared to confer(授予,给予) a greater than twofold increase in risk for these molecularly-defined tumors, compared to women without diabetes.”Knowing that diabetic women have these findings should help to facilitate(促进,帮助) more appropriate colorectal cancer prevention and treatment options,” says Anthony Razzak, M.D., a Mayo Clinic research fellow and presenter11 at the conference. “Our findings may lead to new strategies for colon cancer screening, chemotherapy(化学疗法) and chemoprevention(化学预防) in women with diabetes.””From a research perspective, this information allows us to clarify how environmental exposures and other risk factors might effect tumor formation at a molecular level,” says Dr. Razzak. For future projects, the researchers will work to understand more about the biology of colorectal cancer and how it is influenced by diabetes, as well as other chronic12 conditions and exposures. They hope to use that information to improve patient care.”Unfortunately, diabetes and colon cancer are both very common in the United States, so making links between these disorders13 has substantial public health implications,” says Dr. Limburg.点击收听单词发音  1diabetes   n.糖尿病参考例句:In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者,医生告诫他们不要吃糖。Diabetes is caused by a fault in the insulin production of the body.糖尿病是由体

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